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norskBlar i forfatter "Kondratyev, Timofey"
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Autoregulation of Cerebral Blood Flow During 3-h Continuous Cardiopulmonary Resuscitation at 27°C
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-09)Introduction: Victims of accidental hypothermia in hypothermic cardiac arrest (HCA) may survive with favorable neurologic outcome if early and continuous prehospital cardiopulmonary resuscitation (CPR) is started and continued during evacuation and transport. The efficacy of cerebral autoregulation during hypothermic CPR is largely unknown and is aim of the present experiment.<p> <p>Methods: ... -
Comparison between two pharmacologic strategies to alleviate rewarming shock: vasodilation vs. inodilation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)Rewarming from hypothermia is often challenged by coexisting cardiac dysfunction, depressed organ blood flow (OBF), and increased systemic vascular resistance. Previous research shows cardiovascular inotropic support and vasodilation during rewarming to elevate cardiac output (CO). The present study aims to compare the effects of inodilatation by levosimendan (LS) and vasodilation by nitroprusside ... -
Continuous hemodynamic monitoring in an intact rat model of simulated diving
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)Cardiovascular risk is elevated in divers, but detailed information of cardiac function during diving is missing. The aim of this study was to apply an intact rat model with continuous monitoring of cardiac left ventricular (LV) function in a simulated diving experiment. Thirteen rats were inserted with a LV pressure–volume catheter and a pressure transducer in the femoral artery to measure hemodynamic ... -
Cooling to hypothermic circulatory arrest by immersion vs. cardiopulmonary bypass (CPB): Worse outcome after rewarming in immersion cooled pigs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)Introduction: Cooling by cardiopulmonary bypass (CPB) to deep hypothermic cardiac arrest (HCA) for cardiac surgical interventions, followed by CPB-rewarming is performed on a routine basis with relatively low mortality. In contrast, victims of deep accidental hypothermia rewarmed with CPB generally have a much worse prognosis. Thus, we have developed an intact pig model to compare effects on ... -
Effects of cold decompression on hemodynamic function and DCS risk in a dry diving rat model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-03)Background: Diving in cold water is thought to increase the risk of decompression sickness (DCS), especially if the diver is cold during decompression. In this study, we investigated hemodynamic function and DCS risk in an animal model, where cold decompression was followed by rewarming at the surface. <p> <p>Methods: Nine female Sprague Dawley rats had pressure-volume catheters inserted into ... -
Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-23)Victims of severe accidental hypothermia are prone to fluid extravasation but rarely develop lung edema. We hypothesize that combined hypothermia-induced increase in pulmonary vascular resistance (PVR) and a concomitant fall in cardiac output protect the lungs against edema development. Our aim was to explore in hypothermic- isolated blood-perfused rat lungs whether perfusion at constant ... -
Effects of morphine or ketamine in rats with asphyxial cardiac arrest: a pilot study
(Conference object; Konferansebidrag, 2017-05-06)Acute hypoxia results in uncontrolled release of glutamate and the consequent stimulation of N-methyl-D-aspartate (NMDA) receptors, which affects the whole ionic homeostasis and finally activates apoptosis of neurons. A potential therapeutic approach to prevent this sequence of events is a blockade of NMDA receptors. Meanwhile, in different models of acute hypoxia, activation of delta-opioid ... -
Effects of rewarming with extracorporeal membrane oxygenation to restore oxygen transport and organ blood flow after hypothermic cardiac arrest in a porcine model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)We recently documented that cardiopulmonary resuscitation (CPR) generates the same level of cardiac output (CO) and mean arterial pressure (MAP) during both normothermia (38 °C) and hypothermia (27 °C). Furthermore, continuous CPR at 27 °C provides O2 delivery (ḊO2) to support aerobic metabolism throughout a 3-h period. The aim of the present study was to investigate the effects of extracorporeal ... -
Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-29)Introduction: Due to functional alterations of blood platelets and coagulation enzymes at low temperatures, excessive bleeding is a well-recognized complication in victims of accidental hypothermia and may present a great clinical challenge. Still, it remains largely unknown if hemostatic function normalizes upon rewarming. The aim of this study was to investigate effects of hypothermia and rewarming ... -
Extracorporeal rewarming from experimental hypothermia: Effects of hydroxyethyl starch versus saline priming on fluid balance and blood flow distribution
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)Rewarming by extracorporeal circulation (ECC) is the recommended treatment for accidental hypothermia patients with cardiac instability. Hypothermia, along with initiation of ECC, introduces major changes in fluid homeostasis and blood flow. Scientific data to recommend best practice use of ECC for rewarming these patients is lacking, and no current guidelines exist concerning the choice of priming ... -
Functional recovery after accidental deep hypothermic cardiac arrest: Comparison of different cardiopulmonary bypass rewarming strategies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)Introduction: Using a porcine model of accidental immersion hypothermia and hypothermic cardiac arrest (HCA), the aim of the present study was to compare effects of different rewarming strategies on CPB on need for vascular fluid supply, level of cardiac restitution, and cerebral metabolism and pressures.<p> <p>Materials and Methods: Totally sixteen healthy, anesthetized castrated male pigs were ... -
Inhibitor of neuronal nitric oxide synthase improves gas exchange in ventilator-induced lung injury after pneumonectomy.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the ...
